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The enzyme CSE catalyzes the synthesis of cysteine from cystathionine, and its promoter contains a binding site for Nrf2, and expression can be triggered by oxidative stress (199)

453 Novel agents, including antibodies, ADCs, DDR inhibitors, epigenetic therapies, PROTACs, and nanomedicine delivery platforms, offer new opportunities for resistance-targeting interventions

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Aging is associated with increased ROS in GCs and reduced expression of genes involved in peroxide detoxification, NADPH production, and mitochondrial electron transport (Fig

To date, more than 100 natural medicine monomers have been reported to activate the GSH system by several mechanisms to protect the heart from oxidative stress

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