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The SELECT trial, published in the New England Journal of Medicine in 2023, demonstrated that semaglutide significantly reduced major adverse cardiovascular events in patients with established cardiovascular disease and overweight or obesity, representing a landmark finding for GLP-1 receptor agonists in cardiovascular risk reduction

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However, it is important to note that many of these serotonin-targeted weight-loss therapies require an intact melanocortin system in order to be effective [108]

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10.1111/j.1463-1326.2010.01214.x 106 LimK

No signs of damage were observed upon arrival