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2 Materials and methods 2.1 Materials GIP(1-42) was purchased from Genscript (Piscataway, NJ), tirzepatide was purchased from Focus Bioscience Pty (St Lucia, QLD, Australia), GIP(1-30)NH 2 was synthesized in-house as described in the Supplementary Material (Supplementary scheme S1

Avoiding direct sunlight and heat exposure Heat exposure rapidly degrades semaglutide effectiveness

While the research base for microdosing, specifically, is still developing, and lower-dose protocols are being explored, though clinical evidence for efficacy at sub-therapeutic doses remains limited

A summary of their status, interventions, follow-up durations, and main outcomes is shown in Table 4

doi: 10.1016/j.clim.2020.108544 29 JainS

Probiotics Antimicrob Proteins (2019) 11:64854