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By selectively addressing zinc imbalances in specific subcellular compartments, emerging strategies seek to restore cellular homeostasis across various disease contexts

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Although brain infarction volume reduction did not reach statistical significance, motor performance in the rotarod test significantly recovered in DSIP-treated animals compared to vehicle controls confirming a functionally relevant neuroprotective effect at the behavioural level and establishing intranasal delivery as a viable route for CNS DSIP research

This suggests that their enrichment may reflect shared mitochondrial gene activation rather than distinct disease-specific processes