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Conjugation of alendronate to nanoparticle surfaces enables preferential accumulation at bone tumor sites, as demonstrated in multiple preclinical studies ( IL-11R represents another promising target for bone-specific drug delivery

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Rapid glucose reduction associated with GLP-1 therapy has been linked to worsening of diabetic retinopathy in some studies, particularly the SUSTAIN-6 trial with semaglutide

This involves enhancing glucose-dependent insulin secretion, providing a physiological response to elevated blood glucose levels after a meal

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