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ENL degradation by dHTC1 proceeds through CRL4 CRBN We next used a forward genetic screen to identify the effectors responsible for dHTC1 activity, which was enabled by a dual fluorescence ENL stability reporter (ENLTagBFPP2AmCherry) expressed in KBM7 cells (Extended Data Fig

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Reactive nitrogen species also increase due to aberrant protein catabolism, exacerbating cellular oxidative stress 104

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From there, scientists began studying whether this compound might support repair in other tissues

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