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The good news is that lifestyle and diet changes can reduce the frequency and severity of symptoms

GLP-1 RAs exert their therapeutic effects through multiple mechanisms, primarily by stimulating the GLP-1 receptor, which in turn enhances insulin secretion, suppresses glucagon release, delays gastric emptying, and promotes satiety

Licensed options in the UK include orlistat (oral), semaglutide 2.4 mg (Wegovy, approved by NICE TA875 for eligible patients), and tirzepatide (Mounjaro for type 2 diabetes

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While consistency is the most important factor, many people find the best results by taking them in the morning on an empty stomach