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Some researchers use higher doses for more severe symptoms
PubMed alternative-therapies.com 5
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The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location
A 2025 systematic review examined all published literature on the compound, identifying 544 total articles published between 1993 and 2024
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