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Pain modulation and interaction with endogenous opioid systems represent another productive area of DSIP investigation

J Altern Complement Med 17:827833 Farr SA, Poon HF, Dogrukol-Ak D, Drake J, Banks WA, Eyerman E, Butterfield DA, Morley JE (2003) The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice

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1c) and preliminary mutational studies on Tyr110 show indeed similar effects to Lys105 (Supplementary Figs 18 and 19)