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The enzymatically active tetramer (tet-PKM2) has a high affinity for glycolytic substrates and enzymes to promote the conversion of glucose to pyruvate or lactate, while the transcriptionally active dimer (di-PKM2) translocates to the nucleus and acts as a nuclear transcriptional coactivator that regulates gene expression while allowing the accumulated glycolytic intermediates to generate cellular building block components (such as nucleotides and lipids) through the phospholipid synthesis and amino acid synthesis [93,94,95,96]

(PubMed) Heresi G, Castillo-Duran C, Munoz C, Arevalo M, Schlesinger L

They solve different problems, which is why a lot of people end up using both

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At first, I assumed constipation or hunger

Furthermore, AC exhibits a mild inhibitory effect on platelet aggregation in vitro, regardless of whether aggregation is induced by adenosine diphosphate or arachidonic acid (Campo et al