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Half-life: ~4 hours (short-acting typically studied twice daily)
Midlife fruit and vegetable consumption and risk of dementia in later life in Swedish twins
They are fast-acting and effective, but long-term use causes skin thinning, telangiectasia (visible blood vessels), and tachyphylaxis (reduced effectiveness over time)
Patients with a BMI of 30 kg/m or greater, or BMI of 27 kg/m with weight-related comorbidities (hypertension, type 2 diabetes, dyslipidemia), generally meet baseline medical criteria for GLP-1 therapy
doi: 10.3389/fnagi.2021.741923 211 QiLChenZWangYLiuXLiuXKeLet al
But many GLP-1 users do not need another program layer
