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doi:10.1016/j.mrgentox.2006.05.006

To better understand the human relevant pathways modulated by semaglutide, we analyzed gene expression changes in microglia, endothelial cells, and pericytes, focusing on their overlap with AD-associated genes

Therefore, the present findings should be interpreted within the context of a weight-focused modeling framework and integrated with broader clinical evidence when informing treatment decisions

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Percent change in weight from baseline to week 72 Primary outcome: Results Among participants with obesity but without diabetes, treatment with tirzepatide was superior to treatment with semaglutide with respect to reduction in body weight and waist circumference at week 72

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