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[10] showed that metformin enhanced the expression of the genes encoding the receptors for both GIP and GLP-1 ( Gipr and Glp1r , respectively) in mouse islets and also increased the effects of GIP and GLP-1 on insulin secretion from beta cells

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Reversal of enhanced pancreatic cancer growth in diabetes by insulin

They may result in particular allergic reactions if they are performed incorrectly