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This mechanism naturally limits absorption when B12 is consumed in large quantities, with excess amounts typically eliminated through the kidneys without causing harm
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For example, 8 weeks daily followed by ongoing maintenance at 3 times weekly
Extreme restriction is unnecessary and often counterproductive, causing metabolic slowdown that persists beyond the protocol
Plant Physiol 183:112122 Torres MA, Dangl JL, Jones JD (2002) Arabidopsis gp91phox homologues AtrbohD and AtrbohF are required for accumulation of reactive oxygen intermediates in the plant defense response
Lifehacks: If you think you may need to boost your glutathione levels due to oxidative stress and genetic polymorphisms, there are multiple way you could approach this: Reduce the need for glutathione (reduce toxins) Add more cysteine-rich foods its the limiting factor for glutathione synthesis Also, add glycine if it is limited in your diet Directly supplement with liposomal or IV glutathione Indirectly supplement with cofactors, amino acids (caution here) Avoiding toxicants: Avoiding exposure to the toxicants that deplete glutathione will increase your overall glutathione levels and give you more resistance to oxidative stress
