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Clinical Insights and Research Updates Semaglutide is widely used for managing type 2 diabetes and aiding in weight loss, but its effects on the digestive system, particularly causing bloating, have prompted ongoing research
In the multicenter PIVENS ( PI oglitazone versus V itamin E versus placebo for the treatment of N onalcoholic S teatohepatitis) trial, 247 subjects with MASH but not diabetes mellitus were randomized to receive 30 mg/day of pioglitazone (an insulin-sensitizing drug), 800 IU/day (536 mg/day) of RRR --tocopherol, or a placebo for 96 weeks (97)
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Revised Cochrane risk of bias tool for randomized trials (RoB 2.0) 2016