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In particular, studies should assess the potential synergistic or antagonistic effects between agents targeting converging biological pathways (e.g., SGLT2i and GLP-1 RAs) to inform rational polypharmacy

Glucagon is a peptide hormone secreted by the pancreas that helps regulate blood sugar

doi:10.1152/ajplegacy.1959.197.1.217 43

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(Yes, and Heres Why Thats Actually Good) Someone asked me if its normal to feel hungry or have a sweet tooth on GLP-1, and honestly

Glucagon is liberated from pancreatic cells by PC2, wherea GLP-1 and GLP-2 are liberated from the intestinal L cells by PC1/3