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Hypoxia causes the production of ROS, which inhibit the degradation of the hypoxia-inducible factor 1 (HIF-1) (78)
Mbemba F, Houbion A, Raes M, Remacle J
Rotate sites and apply a cool compress
In studies the application was not circumferential, and in some instances, exceeded well into the submucosal tissue, and in others, not deep enough into the epithelium
It helps cells regenerate and repair, but doesnt play a direct role in skin brightening or melanin control
Presented for research literature review only Bodea F et al
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