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Berberine's proposed mechanism of action involves activation of AMP-activated protein kinase (AMPK), an enzyme that regulates cellular energy metabolism

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pRTECs are interconnected by gap junctions and tight junctions, and when ferroptosis occurs in one cell, NADPH can simply diffuse from adjacent cells to the dead cell via cell junctions, thus making the adjacent cells less antioxidant and more sensitive to ferroptosis [101, 102]