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Unlike iPSC-derived models generated through directed differentiation, renal tumor organoids are established directly from patients tumors and are primarily used to preserve tumor-specific biological characteristics and predict sensitivity or resistance to anticancer drugs, thereby supporting personalized treatment selection ( 4 Epidemiological research of kidney diseases using organoids 4.1 Application of organoids in epidemiological data analysis of kidney diseases By investigating organoids derived from diverse populations and geographic regions, the roles of genetic and environmental factors in the onset and progression of kidney diseases can be elucidated