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Safety Profile: What You Actually Need to Know No drug class with this breadth of benefit is without side effects, and intellectual honesty requires addressing them directly
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Canagliflozin (Invokana, Vokanamet): signal of increased risk of lower extremity amputations observed in trial in high cardiovascular risk patients
A 2019 review in Nutrients examining NAD+ precursor safety in human clinical trials found oral NMN and NR well-tolerated at doses up to 1,000 mg/day with no serious adverse events reported
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