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Staying well hydrated, maintaining regular meal timing even with reduced appetite, and avoiding known dietary migraine triggers during the adjustment period can help minimize early headache burden

In cultured H9c2 cells, GLP-1RAs attenuate the production of mitochondrial and intracellular reactive oxygen species (ROS) induced by methylglyoxal

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Detection of p-NF-B p65, NLRP3, caspase-1 and ASC mRNA expression in CCD-841CoN cells by RT-qPCR We established an in vitro cellular inflammation model using UC cells and administered pharmacological interventions

Tirzepatides dual GLP-1R and GIPR agonism may confer distinct anti-inflammatory effects, some of which persist even when neuronal GLP-1R signaling is impaired