retatrutide phase 2 obesity nejm 2023 jastreboff on X: "Original Article: Triple–Hormone-Receptor Agonist for — A Trial https://t.co/jNL1GNnHPT #ADA23 https://t.co/NN12Qgg2cV" / X Retatrutide (Eli Lilly's triple GLP-1/GIP/Glucagon

doi: 10.1016/j.lfs.2021.120099 135 GriffithsMJHorneAWGibsonDARobertsNSaundersPTK

Mechanisms In summary, pre-clinical studies of anti-inflammatory signalling and findings from and observational studies of clinical datasets suggest GLP-1 RAs may confer dual metabolic and disease-modifying advantages in IBD, particularly in people with obesity, but evidence from prospective trials is lacking [2]

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Negative control of p53 by Sir2 promotes cell survival under stress

Similarly, of the few SyeA homologues detectable by sequence-based searches, that of Liberibacter has been noted to have structural similarity to EspG 22