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Oxidative stress induces the expression of Trx [165, 166], which is believed to protect against oxidative stress by (a) modulating signal transduction properties of ROS [167, 168], (b) scavenging radicals [169], (c) reducing intracellular disulfides, (d) selectively modulating the DNA-binding of transcription factors like AP-1 [170, 171] and NF-kB [172], (e) preventing apoptosis by binding to apoptosis signal-regulating kinase 1 (ASK-1) [173], (f) donating electrons to periredoxins, which are involved in the reduction of peroxides [174, 175], (g) reactivating partially oxidized and inactivated recombinant TTase [148], and (h) selectively inducing several antioxidant gene expressions [176]

PMID 22232016

Read the full article covered by Nutritional Outlook here: To view or add a comment, sign in More Relevant Posts Green Coffee Bean Extract: Selecting Between Chlorogenic Acid Potencies and Solubility Grades Green Coffee Bean Extract is derived from unroasted Coffea beans and standardized to chlorogenic acids as the primary active marker for B2B quality consistency

FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication

Blonde, L., Umpierrez, G

Body Composition Some patients ask about lean body mass or fat distribution, but Sermorelin is not a stand-alone weight-loss treatment