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Furthermore, long-term use of these medications has been shown to reduce the risk of developing type 2 diabetes by sevenfold compared to placebo
This was based largely on the FLOW trial, which found that patients with CKD and Type 2 diabetes who took semaglutide had a significantly lower risk of major kidney events (kidney failure, dialysis, transplant)
GLP-1 acts on neighbouring GLP-1R-positive afferent nerve terminals within the taste bud, thereby forming a local regulatory circuit that influences the early encoding of taste signals (13)
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