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Merging PROTAC and molecular glue for degrading BTK and GSPT1 proteins concurrently
Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans
OA Table 2 shows that while they were able to get statistical significance for their primary endpoint (which was a composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke,) they did not achieve statistical significance for any of their confirmatory or supportive secondary endpoints, including the individual endpoints from the composite
Identitt und Reinheit per HPLC und LC-MS, bei aktuellen Chargen zustzlich Schwermetalle und Endotoxine
ARRIVE guidelines 53 were consulted to accurately report the animal experiments described below
