For example, Changpusan has demonstrated significant antidepressant effects in the CUMS model, with its impact on tryptophan metabolism confirmed through metabolomic profiling [547]
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In the context of Wegovy and GLP-1 drugs: When Novo Nordisk couldnt meet demand for Wegovy due to supply chain limitations, compounding pharmacies began making "semaglutide" copies to meet the market need
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Although the perception of some clinicians is that patients may be less receptive of the GLP-1RA because they require subcutaneous injections, clinical trials have shown that patients do not associate injectable therapies with a negative effect as long as there is clinical efficacy (103, 104)