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Published research has investigated Tirzepatide in the context of: Background on Incretin Research The incretin system comprises hormones released from the gut in response to nutrient intake that modulate insulin secretion from pancreatic beta cells
REMODEL, A Research Study to Find Out How Semaglutide Works in the Kidneys Compared to Placebo, in People With Type 2 Diabetes and Chronic Kidney Disease (NCT04865770)
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Their results demonstrate that GLP-1, through an unknown mechanism, can preserve axonal and neurofilament structure despite the induction of progressive neurotoxicity, thus illustrating neuroprotective properties that can be leveraged against disorders in the central nervous system [60]
TRIUMPH-3 (NCT05882045) Design: Phase 3, 80-week, randomised, double-blind, placebo-controlled trial in adults with severe obesity (Class 2 or 3, BMI 35) and established cardiovascular disease, with or without type 2 diabetes
Higher doses may increase the risk of side effects, while underdosing may not provide the full therapeutic effects
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