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Results: In the reported cases of semaglutide (n = 2047) and liraglutide (n = 4175), semaglutide had a higher pooled ROR and later pooled time-to-onset median of GADRs compared with those of liraglutide (5.53, 95% CI 5.23 5.85 vs 3.95, 95% CI 3.81 4.10
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Table 1) of MTCs
They appear after each dose increase, peak during the first week at the new dose, and gradually subside over 2 to 4 weeks
In a large clinical comparison, adults with overweight or obesity lost more body weight on tirzepatide than on semaglutide in real-world care, as shown in a JAMA Internal Medicine cohort study
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