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Unlike statins, semaglutide also reduces appetite, supports weight loss, and improves blood sugar controlmaking it particularly effective for patients with metabolic syndrome (a cluster of conditions including high cholesterol, high blood pressure, excess belly fat, and insulin resistance)
The phase 2 trial published in The New England Journal of Medicine in 2023 enrolled adults with obesity without type 2 diabetes and demonstrated dose-dependent weight loss of up to 24.2% of body weight at the highest dose over 48 weeks results that attracted considerable scientific and media attention
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This is well-established in the bariatric surgery literature, and the same principles apply to medication-assisted weight loss
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