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Semaglutide medications are approved for the treatment of type 2 diabetes as an accompaniment to diet and exercise, typically as once-weekly injections or once-daily oral drugs

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In patients with DM2 the incretin response is diminished, but the insulinotropic effect of GLP-1 is conserved.28 Under normal conditions GLP-1 has a short half-life (approximately 2 min), as it is rapidly degraded by dipeptidylpeptidase 4, so GLP-1 analogues resistant to this enzyme have been developed for the treatment of DM2.29 arGLP-1: glucagon-like peptide 1 receptor agonist

In animal models of diet-induced obesity, co-administration of cagrilintide and semaglutide produced additive suppression of food intake, greater fat mass loss, and improved metabolic markers beyond what either compound achieved alone

Gastrointestinal Side Effects and Alcohol Common semaglutide side effects include nausea, vomiting, diarrhea, and constipationall of which are gastrointestinal in nature

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