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Researchers at the University of Zagreb first characterized it in the early 1990s, and it's been generating interest ever since

Some users report needing 20-50% higher nasal doses to achieve equivalent effects, though individual variation is substantial

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However, the publicly available evidence does not support broad conclusions about complete toxicological safety, long-duration exposure, reproductive or developmental risk, immunological risk, genotoxicity, or suitability for any non-research application