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For more information, please read about compounded GLP-1s, and listen to listen Dr

Additional dual and triple agonists acting on GLP-1, GIP, and glucagon receptors are now in late-stage clinical development

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These results project that retatrutide may have a greater efficacy than tirzepatide and semaglutide due to its triple action at GLP-1, GIP, and glucagon receptors

Marie Spreckley, a research programme manager at the University of Cambridge, offered measured expert commentary via Medscape, calling the topline findings "very encouraging" but noting that "direct cross-trial comparisons should always be made with caution." Side Effects Climb with Dose The drug's exceptional efficacy at the highest dose comes with a correspondingly elevated side effect burden