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Four patients (6.90%) were taking no ASMs, 11 patients (18.96%) were on monotherapy with one ASM, while 43 patients (74.14%) were on polytherapy of two or more ASMs
For AD specifically, given the well-established effects of GLP-1 RAs on tau hyperphosphorylation, we recommend that future GLP-1 RA clinical trials focus on the tau-positive subgroup of patients
Chemotherapy drugs, for example, doxorubicin, cisplatin, and cyclophosphamide, generate ROS that trigger a series of lipid peroxidation events that likely destabilise cellular membranes [137, 138]