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GLP-1 drugs were not tested in pregnant populations, and animal studies have raised concerns about fetal development
Association between triglyceride glucose index and risk of cerebrovascular disease: systematic review and meta-analysis
When Fiber Isn't Enough: Osmotic Laxatives to Know About American Journal of Gastroenterology found good evidence to recommend PEG 3350 as a first-line treatment for constipation because it is well-tolerated and generally produces few side effects
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For patients meeting NICE criteria for weight management therapy (BMI 35 kg/m with adjustment for ethnicity, presence of weight-related comorbidities, and treatment through specialist weight management services), the dual benefit of weight reduction and blood pressure lowering may be particularly valuable
Best results appear within 4-8 weeks of consistent use combined with regular activity
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