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While these preliminary results appear promising, larger randomized controlled trials are needed to establish definitive efficacy

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5) Anti-Atrophy Protection in Human Contexts IGF-1 signaling counteracts pathways linked to muscle loss (e.g., ubiquitinproteasome activity), while enhancing satellite cell activity key for maintaining lean mass during reduced activity or aging in human settings

Clapper ML, Hoffman SJ and Tew KD

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