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Immune cells are highly sensitive to oxidative stress during activation, and the intracellular glutathione pool can influence inflammatory signaling pathways and the balance between pro-oxidant and antioxidant responses
However, the research on this is mixed
The symptoms mimic medication side effects, reduced desire, fatigue, and mood changes, which means the nutritional component gets overlooked entirely
This discrepancy may be associated with the heightened sensitivity of germ cells to oxidative damage and proteostasis perturbation during active proliferation, meiosis, and chromatin remodeling
Reported adverse effects of IV glutathione include adverse cutaneous eruptions including potentially fatal Stevens-Johnson syndrome and toxic epidermal necrolysis, severe abdominal pain, thyroid dysfunction, renal dysfunction, and lethal complications such as air embolism or potentially fatal sepsis due to incorrect/unsterile method of IV administration, with side effects on the use of injectable glutathione for skin lightening including toxic effects on the liver, kidneys, and nervous system
Sun M, Wang X, Lu Z, Yang Y, Lv S, Miao M, et al
