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Diet and lifestyle interventions Bulking agents like dietary fiber and fiber supplementation Laxatives and stool softeners (eg, lubiprostone and polyethylene glycol) Antidiarrheals such as loperamide or bile acid sequestrants (eg, colesevelam) Antispasmodic medications (eg, pinaverium bromide) Serotonergic agents, which can be common classes of antidepressants (eg, tricyclic antidepressants [TCAs] or selective serotonin reuptake inhibitors [SSRIs]) or those that locally interact with serotonin receptors (agonists or antagonists) in the gut (eg, alosetron) Antibiotics to treat SIBO (rifaximin) What are Some Novel & Emerging Therapies for IBS

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