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Its primary job is to take a methyl group and attach it to nicotinamide (a form of vitamin B3), effectively deactivating it and preparing it for excretion
For a standard 70 kg human, the calculated HED is 84.7 mg/day
Exercise particular caution with: Blood pressure medications (nitric oxide effects may alter blood pressure) Immunosuppressive drugs (healing modulation could interact) Growth hormone or related medications (receptor interactions possible) Frequently Asked Questions Glossary of Terms References Sikiric P, et al
Genetic studies were assessed for quality using the Newcastle Ottawa Scale plus additional criteria that included consideration of Hardy Weinberg equilibrium, power of the study, population stratification and correction for multiple comparisons
But, you can take it post-workout too