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As countries grapple with rising obesity and diabetes burdens, semaglutide has captured global headlinesnot only for its clinical efficacy but also for how Novo Nordisk has handled its market exclusivity in Canada through patent portfolio management and regulatory data exclusivity
Neuroimaging studies reveal that GLP-1 agonists increase activation in the prefrontal cortex and hippocampusbrain regions critical for focus, memory, and executive planning
Before initiating Wegovy, healthcare professionals should establish a comprehensive baseline assessment including: Complete medical history and medication review Physical examination with baseline weight, BMI, and blood pressure Blood tests: HbA1c (if diabetic or at risk), lipid profile, liver function, kidney function, and thyroid function Assessment for contraindications (the UK SmPC lists hypersensitivity to semaglutide or any excipients as the only contraindication) Documentation of any existing neurological symptoms According to NICE TA875, Wegovy should be prescribed within specialist weight management services
Compounded semaglutide contains the same active molecule as Wegovy
The first application in PD was performed in 13 medication-resistant patients that received MRgFUS pallidothalamic tractotomy and had a significant UPDRS score reduction at 3 months post intervention, thus indicating feasibility, safety, and accuracy of the method (Magara et al
Silberman & Taylor (2023)
