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Many subjects with oral mucosal melanin hyperpigmentation, whether physiological or pathological in origin, are usually unaware of it so cannot give information about its duration or progression

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Further research should focus on conducting more clinical trials targeting specific OA subtypes (e.g., inflammatory OA) and investigating the combined use of TNF and IL-6 inhibitors with other therapies, such as stem cell therapy and chondroprotective agents

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