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Understanding how GSH level and synthesis velocity depend on the sex hormones is an extremely important question since oxidative stress contributes to the risk for heart disease [8] and cancer [9] , and oxidative stress is reduced by GSH via the enzyme GPX [Figure 1]

4.1 The ApelinAPJ axis Apelin was identified as the endogenous ligand for the APJ receptor, a G proteincoupled receptor structurally related to the angiotensin II type 1 receptor but functionally distinct from the reninangiotensin system ( Despite these favorable metabolic effects, enthusiasm for apelin-based therapeutics waned due to its potent cardiovascular actions, including vasodilation and positive inotropy

Importantly, Gclc -deficient FoB accumulate ROS (Fig

et al., 2020), demonstrated a different response in cancer cells, as they suppressed autophagy to enhance CPs chemosensitivity (Lai et al., 2020

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