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If you're in group 2, that's when to have the conversation with your provider about whether to add daily Miralax, hold the current dose longer before escalating, or consider dose reduction
The insulin resistance in PCOS might also occur independently of body weight, due to inherited post-receptor defects in insulin signalling that affects metabolism and mitotic pathways, not only in classic insulin target tissues, such as skeletal muscle, liver, and adipose tissue, but also in the non-classical target tissues, such as pituitary and ovary [12, 16]
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Mol Syst Biol 16:MSB199270 Karatoprak G (2022) Vanillin
Effect : This interaction may decrease the blood sugar-lowering efficacy of JANUVIA 100MG TABLET, potentially resulting in higher blood glucose levels (hyperglycemia)
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