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Older adults, those with cardiac conditions, and patients on insulin or other glucose-lowering agents may benefit from slower titration or plateau at lower doses to avoid hypoglycemia and cardiovascular complications

Despite a similar proportion of subjects reporting AEs in all groups, a higher number of AEs were reported with OW s.c

A 2025 systematic review of four randomized controlled trials involving 27,617 participants showed that semaglutide reduces MACE by 19% (relative risk 0.81, 95% CI 0.74-0.88), with additional benefits for cardiovascular death and nonfatal heart attack

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Available from: Accessed June 1, 2025