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"Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor"
Two recent meta-analyses of eight cardiovascular outcome trials (CVOTs) and several other meta-analyses that included non-CVOT studies estimated the reduction in cardiovascular mortality varied between 12 and 15% (Zheng et al., 2018
In breast cancer, transcription factor AP-2 gamma (TFAP2C) is an important transcription factor that regulates estrogen receptor-alpha (ER) and c-ErbB2/HER2 (Her2), which are involved in the establishment of the gene expression pattern observed in different clinical phenotypes of breast cancer [79, 80]
Summary: GLP-1 receptor agonists do not directly cause erectile dysfunction and may potentially improve erectile function in some men through better glycaemic control and weight reduction
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The ability to cross the rat placenta has been described as low and very limited for sotagliflozin and empagliflozin respectively
