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The findings underscore the importance of setting clear expectations with patients early in treatment, including the possibility that more than one medication may be prescribed before a long-term approach is identified

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After propensity-score matching, the two cohorts (26,670 in each cohort, mean age 58.0 years, 45.3% women, 14.7% black, 60.3% white, 6.5% Hispanic) were balanced (Supplementary Table 1)

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