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However, because HGF/c-Met signaling also plays roles in cell proliferation and is implicated in certain cancers, the long-term safety implications of chronic c-Met activation require careful evaluation

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BPC-157 lacks FDA approval as a drug or dietary supplement ingredient approved for human administration

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The first is extracellular matrix biology: fibroblast culture and rat wound-chamber work from the Maquart and Simeon groups reported that GHK-Cu stimulates collagen, glycosaminoglycan and small proteoglycan synthesis while simultaneously upregulating matrix metalloproteinase-2 and its tissue inhibitors, a combined synthesis-and-turnover signature unusual among matrix-active compounds

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