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Zhang 2012)

While some individuals may notice initial changes in appetite and a small amount of weight loss within the first few weeks, significant and sustained weight loss generally unfolds over several months

References Wang, R

In SURMOUNT-1, 72 weeks of tirzepatide induced mean WL of 1622.5% in people without diabetes compared to 2.4% with placebo, with no sign of the weight plateauing, suggesting that there may be further WL with long-term use [46]

Diminishing results despite consistent dosing is another signal

After being phosphorylated, AKT participates in important biological processes such as apoptosis, protein synthesis, and cell cycle progressionAfter being phosphorylated, AKT participates in important biological processes such as apoptosis, protein synthesis, and cell cycle progression