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11,12 For instance, the success of exenatide has not only spurred the development of potent GLP-1 analogs such as liraglutide and semaglutide but also unveiled the vast potential of GLP-1RAs in treating various systemic diseases
Mechanistically, it is described as a monoamine reuptake inhibitor, affecting: Dopamine Norepinephrine Serotonin In weight-management trials, its primary investigational role involved: Appetite regulation Reduced caloric intake Altered reward-driven feeding behavior It is not a GLP-1 analog and does not function via incretin pathways
The molecular design determines how it fits into real-world use
Jan 4 2019;8(1)doi:10.3390/jcm8010045 Milenkovic T, Bozhinovska N, Macut D, et al
STEP 4 is the important counterpoint: weight came back when treatment stopped, so this is a long-term treatment rather than a short course, and whether it is right for you is a decision for the prescribing doctor
When B12 levels are equivocal, additional testing with methylmalonic acid (MMA) and homocysteine levels can provide greater diagnostic accuracy, as both are elevated in true B12 deficiency
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