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If you are currently using sublingual or oral forms of B12 and you are getting symptomatic relief then I wouldnt recommend changing up your method of administration

Calcitriol protects the bloodbrain barrier integrity against ischemic stroke and reduces vasogenic brain edema via antioxidant and antiapoptotic actions in rats

It is also prescribed for the maintenance of healing of erosive esophagitis and for reducing the risk of re-bleeding in adults after initial control of bleeding caused by ulcers

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Is NAC enough on its own for detox support