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These metabolic changes were supported by alterations in the gene expression of choline metabolism-related enzymes, such as choline dehydrogenase ( Chdh ), betaine-homocysteine methyltransferase ( Bhmt ), and DMG dehydrogenase ( Dmgdh ), and glycerophosphocholine phosphodiesterase 1 ( Gpcpd1 )

Report No.: NCT03690206

This triple mechanism produced 24.2% mean weight reduction in Phase 2 trials, exceeding both comparators

Statistical analyses The primary analysis estimand was the average treatment effect on the treated (ATT), estimated using a propensity score (PS) weighting approach in the on-treatment cohort

In addition, a catalytically active soluble form of DPP4 is also present in plasma